Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice

作者：Nava Catorce Miryam; Acero Gonzalo; Pedraza Chaverri Jose; Fragoso Gladis; Govezensky Tzipe; Gevorkian Goar^*

来源：Journal of Neuroimmunology, 2016, 297: 20-27.

DOI：10.1016/j.jneuroim.2016.05.008

• Neuroinflammation
• alpha-Mangostin
• Lipopolysaccharide
• Peripheral infection
• Interleukin-6
• Cyclooxygenase-2

Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases. Molecules with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration as an adjuvant therapeutic strategy. In the present study we have demonstrated that alpha-mangostin (alpha-MG), a natural xanthone purified from mangosteen pericarp, reduced brain levels of pro inflammatory cytokine interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and 18 kDa translocator protein (TSPO) in an animal model of peripheral LPS-induced neuroinflammation. We think that evaluation of alpha-MG as an adjuvant treatment in preclinical models of AD, PD, multiple sclerosis and other diseases with known shared pathology merits further consideration.

• 出版日期2016-8-15