A convenient and efficient one-pot method for the synthesis of novel acridine-calix[4] arene derivatives as new DNA binding agents via multicomponent reaction

作者：Mirza Aghayan Maryam^*; Yarmohammadi Masoud; Zadmard Reza; Boukherroub Rabah

来源：Supramolecular Chemistry, 2014, 26(5-6): 442-449.

DOI：10.1080/10610278.2013.832763

• DNA binding agent
• multicomponent reaction
• fluorescence titration
• acridine-calix[4]arene derivatives

A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by H-1 NMR, C-13 NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA. A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by H-1 NMR, C-13 NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA.

• 出版日期2014-6-3