Access to Imidazo[1,2-a]imidazolin-2-ones and Functionalization through Suzuki-Miyaura Cross-Coupling Reactions

作者：Grosse Sandrine; Pillard Christelle; Himbert Franck; Massip Stephane; Leger Jean Michel; Jarry Christian; Bernard Philippe; Guillaumet Gerald^*

来源：European Journal of Organic Chemistry, 2013, 2013(19): 4146-4155.

DOI：10.1002/ejoc.201300268

• Imidazo[1
• 2-a]imidazolinones
• Palladium
• Fused-ring systems
• Cross-coupling
• Synthetic methods

We report herein a synthetic pathway to new 6(5)-bromo-5(6)-methylimidazo[1,2-a]imidazolin-2-ones. The synthetic potential of these scaffolds was demonstrated by displacing bromine by Suzuki-Miyaura cross-coupling reactions. A large panel of boronic acids (aryl, heteroaryl or vinyl) could easily be introduced, giving access to a large and diversified library of 6(5)-substituted 5(6)-methylimidazo[1,2-a]imidazolin-2-ones.

• 出版日期2013-7