An efficient synthesis of bis-purine derivatives by a PPh3-catalysed double addition of dialkylated xanthine derivatives to alkyl propiolates

作者：Shams Nasim; Mosslemin Mohammad Hossein; Anaraki Ardakani Hossein

来源：Journal of Chemical Research, 2015, 39(9): 499-501.

DOI：10.3184/174751915X14396278385301

• purine
• xanthines
• alkyl propiolates
• triphenyl phosphine

Reaction between 5,7-dialkylated xanthine derivatives (2 equiv.) and an alkyl propiolate in the presence of catalytic amounts of triphenyl phosphine yields alkyl 2,3-bis(1,3-dialkyl-2,6-dioxo/oxothio-2,3-dihydro-1H-purin-7(6H)-yl)propanoates in excellent yield.

• 出版日期2015-9