Association Between Growth of Geographic Atrophy and the Complement Factor I Locus

作者：Yehoshua Zohar; de Amorim Garcia Filho Carlos Alexandre; Nunes Renata Portella; Gregori Giovanni; Penha Fernando M; Moshfeghi Andrew A; Luo Hongrong; Kang Zhang; Sadda SriniVas; Feuer William; Rosenfeld Philip J^*

来源：Ophthalmic Surgery Lasers & Imaging Retina, 2015, 46(7): 772-774.

DOI：10.3928/23258160-20150730-15

The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P >= .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.

• 出版日期2015-7