Anti Diabetic effect of CL 316,243 (A beta 3-Adrenergic Agonist) by Down Regulation of Tumour Necrosis Factor (TNF-alpha) Expression

作者：Ghorbani Masoud^*; Ardestani Mehdi Shafiee; Gigloo Sedigheh Hatami; Cohan Reza Ahangari; Inanlou Davoud Nouri; Ghorbani Peyman

来源：PLos One, 2012, 7(10): e45874.

DOI：10.1371/journal.pone.0045874

Objective: Obesity is a risk factor for the development of insulin resistance and is one of the most important contributors to the pathogenesis of type2 diabetes, which acts mainly through the secretion of adipokines such as TNF-alpha that may influence insulin sensitivity. TNF-alpha affects many aspects of adipocyte function, such as adipocyte development and lipid metabolism. %26lt;br%26gt;Material and Methods: We demonstrated that there is a correlation between the expressions of TNF-a in retroperitoneal WAT and insulin-resistance in 8 genetically obese fa/fa rats. Treatment of animals with CL 316,243, alpha beta 3-adrenergic agonist, showed an improvement of insulin-resistance that was linked with the suppression of TNF-alpha mRNA expression in WAT. %26lt;br%26gt;Results: These results confirm the association between TNF-alpha expression and the insulin-resistant condition in rats. Our finding indicates that the hyperglycaemia and hyperinsulinemia induced by insulin-resistance correlated positively with the expression of TNF-alpha mRNA in an abdominal WAT depot. Conclusion: We conclude that CL 316,243 possesses both anti-diabetic effects and anti-obesity effects in rodents.

• 出版日期2012-10-4