A Case of Multiple Myeloma Diagnosed by Skin Lesions

作者：Erdogan Fatma Gulru^*; Tugrul Burcu; Gurler Aysel; Heper Aylin Okcu

来源：Turkderm-Archives of the Turkish Dermatology and Venerology, 2010, 44(3): 170-173.

DOI：10.4274/turkderm.44.170

• Multiple myeloma
• amyloidosis
• papular mucinosis

Multiple myeloma, being a malignant proliferation of plasma cells in the bone marrow, has clinical spectrum varying from monoclonal gammopathy with unknown significance to plasma cell leukemia. The presenting symptoms have usually been bone pain, pathologic fractures or repeating infections. In patients with multiple myeloma, amyloid depositions may be seen in the skin. This form, defined as primary systemic amyloidosis, is characterized by light-chain amyloid fibril depositions. Our case applied with multiple, asymptomatic, yellowish papules localized on the face, trunk, oral and genital mucosa, gradually increasing during the last two years. He had no complaints, except for slight weight loss. In routine tests, the patient had no pathological laboratory findings, except high C-reactive protein levels. Further research revealed histopathologic and immunohistochemical findings consistent with amyloidosis. Upon these results, immunoglobulin G levels were measured and found high, and in protein electrophoresis, IgG monoclonal gammopathy was determined. The diagnosis of multiple myeloma is made by bone marrow biopsy. This patient is presented for being an asymptomatic case diagnosed by skin findings of amyloidosis. (Turkderm 2010; 44:170-3)

• 出版日期2010-9