Urination Treatment Drug Oleanolic Acid Affects the Therapy Index of Zidovudine (AZT)

作者：Tailaiti, Alimu; Reheman, Alimu; Lili, Gulizhaer; Li, Ping; Mahemuti, Mulati^*

来源：Latin American Journal of Pharmacy, 2015, 34(1): 188-190.

• Drug-drug interaction
• Oleanolic acid
• Zidovudine (AZT)

The present study aims to determine the drug-drug interaction between urination treatment drug oleanolic acid and anti-HIV drug zidovudine (AZT). The inhibition of oleanolic acid towards in vitro glucuronidation metabolism of AZT was determined. The inhibition potential of oleanolic acid towards the glucuronidation metabolism of AZT was firstly investigated at 150 mu M of AZT; 50, 100, 150, and 200 mu M of oleanolic acid inhibited 14.6, 36.8, 56.4, and 70.4% of AZT glucuronidation activity. Furthermore, the half value (IC50) for the inhibition of oleanolic acid towards the glucuronidation of oleanolic acid was determined at multiple concentrations of AZT. The results showed that IC50 value was 102.5, 122.5, 130, and 140.2 mu M at 100, 150, 250, and 400 mu M of AZT, indicating that higher concentration of oleanolic acid was needed for attach the same inhibition potential with the increasing concentration of AZT. The present study demonstrated the inhibition of herbal ingredient oleanolic acid towards AZT glucuronidation, indicating possible drug-drug interaction between oleanolic acid and AZT.

• 出版日期2015
• 单位新疆医科大学