A new highly oxygenated pregnane and two new 5-hydroxymethylfurfural derivatives from the water decoction of Poria cocos

作者：Chen, Ting; Kan, Yong-Jun; Chou, Gui-Xin^*; Zhang, Cheng-Gang

来源：Journal of Asian Natural Products Research, 2018, 20(12): 1101-1107.

DOI：10.1080/10286020.2017.1383398

• Polyporaceae
• Poria cocos
• pregnane steroid
• 5-hydroxymethylfurfural derivatives
• alpha-glucosidase

A new highly oxygenated pregnane steroid, pregn-7-ene-2 beta,3 alpha,15 alpha,20-tetrol (1) and two new 5-hydroxymethylfurfural derivatives, (5-formylfuran-2-yl)methyl 2-hydroxypropanoate (2) and (5-formylfuran-2-yl)methyl 2-(4-hydroxyphenyl)acetate (3), together with four known compounds, were isolated from the water decoction of Poria cocos. Their structures were established on the basis of extensive spectroscopic analysis. Compound 1 showed moderate inhibitory activity and a known compound (3S,6S)-3-[(1R)-1-hydroxyethyl]-6-(phenylmethyl)-2,5-piperazinedione (5) showed weak inhibitory activity against alpha-glucosidase, respectively.
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• 出版日期2018-12-2
• 单位上海中医药大学; 上海中药标准化研究中心