Body Mass Index (BMI) Is Associated with Microalbuminuria in Chinese Hypertensive Patients

作者：Liu, Xinyu; Liu, Yu; Chen, Youming; Li, Yongqiang; Shao, Xiaofei; Liang, Yan; Li, Bin; Holthoefer, Harry; Zhang, Guanjing; Zou, Hequn^*

来源：International Journal of Environmental Research and Public Health, 2015, 12(2): 1998-2008.

DOI：10.3390/ijerph120201998

• CHRONIC KIDNEY-DISEASE
• RISK-FACTORS
• PREVALENCE
• OBESITY

There is no general consensus on possible factors associated with microalbuminuria in hypertensive patients nor any reported study about this issue in Chinese patients. To examine this issues, 944 hypertensive patients were enrolled in a study based on a cross-sectional survey conducted in Southern China. Multivariate regression analyses were performed to identify the factors related with the presence of microalbuminuria and urinary excretion of albumin. The prevalence of microalbuminuria in hypertensive and non-diabetic hypertensive patients were 17.16% and 15.25%, respectively. Body mass index (BMI), but not waist circumference (WC), were independently associated with microalbuminuria and the values of urinary albumin to creatinine ratio (ACR) based on multiple regression analyses, even after excluding diabetic patients and patients taking inhibitors of the renin-angiotensin system from the analyses. Furthermore, patients with obesity (BMI >= 28) had higher levels of ACR, compared with those with normal weight (BMI <24 kg/m(2)) and overweight (24 kg/m(2)<= BMI < 28). In conclusion, BMI, as a modifiable factor, is closely associated with microalbuminuria among Chinese hypertensive patients, which may provide a basis for future development of intervention approaches for these patients.

• 出版日期2015-2
• 单位广州市妇女儿童医疗中心; 中山大学; 南方医科大学