A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

作者：Gonzalez Baro Ana C^*; Ferraresi Curotto Veronica; Pis Diez Reinaldo; Parajon Costa Beatriz S; Resende Jackson A L C; de Paula Flavia C S; Pereira Maia Elene C; Rey Nicolas A

来源：Polyhedron, 2017, 135: 303-310.

DOI：10.1016/j.poly.2017.07.013

• Oxidovanadium(V)
• Isoniazid
• o-Vanillin
• Structural study
• Cytotoxicity

The interaction of oxidovanadium(V) with INHOVA (the condensation product of isoniazid and o-vanillin) lead to the formation of the ester-like complex [VO(INHOVA)EtO(OH2)]Cl center dot H2O (1). Crystals suitable for Xray diffraction methods were obtained. The complex crystallizes as a dimer in the space group P2(1)/c of the monoclinic system. A detailed analysis, including solid-state vibrational spectroscopy and electronic spectroscopy in DMSO solution, was performed for both INHOVA and complex (1). A complete theoretical study based on DFT was also carried out. The calculations were of valuable assistance in the spectra assignments and interpretation. The electrochemical characterization allows determining the redox behavior of INHOVA and complex (1). Cytotoxicity was assayed against the chronic myelogenous leukemia K562 cell line. The IC50 values obtained denote that both the ligand and complex (1) are good candidates for further studies.

• 出版日期2017-10-15