A New Thermosensitive Poly(N-propionyl-aspartic acid/ethylene glycol) with No Cytotoxicity and Tunable UCST

作者：Di Yingying; Ma Xin; Li Chunxiu; Liu Hongmei; Fan Xueying; Wang Meng; Deng Heying; Jiang Ting; Yin Ziming; Deng Kuilin^*

来源：Macromolecular Chemistry and Physics, 2014, 215(4): 365-371.

DOI：10.1002/macp.201300687

• aspartic polymer
• cytotoxicity
• thermosensitive polymer
• upper critical solution temperature

A new thermosensitive poly(N-propionyl-aspartic acid/ethylene glycol) (PPAE) with no cytotoxicity and an upper critical solution temperature (UCST) is synthesized by polycondensation of l-aspartic acid and ethylene glycol. The chemical structures of the monomer and polymer are confirmed by FTIR and H-1 NMR spectroscopy, and by elemental analysis measurements. Turbidimetric measurements indicate that PPAE shows a reversible UCST phase transition at 1.5-37.6 degrees C in pure water or an alcohol/water mixture. The UCST can be facilely tuned via changing the content of alcohol in water or the normal saline. Moreover, the survival rate of HeLa cells to PPAE is close to 100% within 48 h, demonstrating no cytotoxicity. Such aspartic acid-based polymers with tunable thermosensitivity could be useful in the biomedical field. <boxed-text content-type="graphic" position="anchor"> <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="urn:x-wiley:10221352:media:macp201300687:macp201300687-abs-0001">image</graphic

• 出版日期2014-2
• 单位河北大学