A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides

作者：Sellstedt Magnus; Almqvist Fredrik^*

来源：Organic Letters, 2009, 11(23): 5470-5472.

DOI：10.1021/ol9023024

A novel heterocyclic scaffold with a peptidomimetic backbone structure has been synthesized. The scaffold is formed by insertion of primary amines into a cyclic sulfone to give the corresponding ring-expanded sulfonamides. By varying the amine component, a series of potentially biologically interesting compounds has been synthesized.

• 出版日期2009-12-3