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摘要
Rationale Patient reported outcomes provide new insights into the dynamics of asthma management Further to asthma control and quality of life, self reported side effects of treatment can be assessed with the validated Inhaled Corticosteroid Questionnaire (ICQ)
Objectives To compare patient reported side effects between the inhaled corticosteroids ciclesonide and fluticasone propionate
Methods Patients with moderate or moderate to severe asthma pre treated with a constant dose and type of medication, were randomized in three separate studies 1) once daily cicle sonide 320 mu g (n = 234) or twice daily fluticasone propionate 200 mu g (n = 240), 2) twice daily ciclesonide 320 mu g (n = 255) or twice daily fluticasone propionate 375 mu g (n = 273), and 3) twice daily ciclesonide 320 mu g (n = 259) or twice daily fluticasone propionate 500 mu g (n = 244) Patients rated the side effect questions of the 15 domain ICQ on a 7 point Likert scale (0 = not at all, 6 = a very great deal) during scheduled visits
Results The majority of side effect scores remained similar with ciclesonide but worsened statistically significantly with fluticasone propionate from baseline to the end of the study in within treatment analyses In between treatment analyses of studies 1 and 3 ciclesonide significantly improved total side effect scores (p < 0 025) and 14 out of 30 individual local and systemic domain scores (p < 0 025) compared with fluticasone propionate In Study 2, although ciclesonide improved the majority of scores compared with fluticasone propionate only 'oropharyngeal itching' reached statistical significance (p < 0 025, one sided)
Conclusion Patient perceived side effects differ depending on the type of inhaled corticosteroids used Patients with moderate to severe asthma report less intense side effects assessed with ICQ with ciclesonide th
- 出版日期2010-12
- 单位河北医科大学
