Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese A meta-analysis

作者：Zhang, Zhen^*; Ou, Junke; Cai, Peiling; Niu, Bei; Li, Jian^*

来源：MEDICINE, LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA, e11151, 2018-06.

DOI：10.1097/MD.0000000000011151

• Chinese
• coronary heart disease
• gene polymorphism
• meta-analysis
• paraoxonase 1

Background: The relation has not been reported consistently between the PON1 Q192R polymorphism and coronary heart disease (CHD). To clarify the discrepancy, we performed the present meta-analysis to evaluate the association between the PON1 gene Q192R polymorphism and CHD risk in Chinese population.
Methods: We conducted a comprehensive search of the PubMed, EMBASE, and China National Knowledge Infrastructure databases for all available case-control studies. Two reviewers independently selected studies. Data were analyzed by STATA software package v 12.0.
Results: Thirteen studies investigating the association between the PON1 Q192R polymorphism and risk of CHD were selected in this meta-analysis with 4353 cases and 4882 controls. The association between the PON1 Q192R polymorphism and CHD is statistically significant under the recessive genetic model (R/R vs Q/R+Q/Q, odds ratio [OR]=1.111, 95% confidence interval [CI]=1.017-1.214). We observed no statistical association between PON1 Q192R polymorphism and risk of CHD under allele model (R vs Q, OR=1.087, 95% CI=0.976-1.209), homozygous model (RR vs QQ, OR=1.192, 95% CI=0.949-1.496), and dominant genetic model (Q/R+ R/R vs Q/Q, OR=1.127, 95% CI=0.938-1.354).
Conclusion: This meta-analysis suggests that the PON1 Q192R polymorphism has a weak association with CHD risk in Chinese.

• 出版日期2018-6
• 单位成都大学