Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass

作者：Parrish Stephen M; Yoshida Wesley; Yang Baojun; Williams Philip G^*

来源：Journal of Natural Products, 2017, 80(3): 726-730.

DOI：10.1021/acs.jnatprod.6b00896

Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 35 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 mu M). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.

• 出版日期2017-3