ADC at 3.0 T as a noninvasive biomarker for preoperative prediction of Ki67 expression in invasive ductal carcinoma of breast

作者：Shen, Lu; Zhou, Guoxing; Tong, Tong; Tang, Fei; Lin, Yi; Zhou, Jie; Wang, Yibin; Zong, Genlin; Zhang, Lei^*

来源：Clinical Imaging, 2018, 52: 16-22.

DOI：10.1016/j.clinimag.2018.02.010

• Invasive ductal carcinoma
• Diffusion weighted imaging
• Ki67
• Magnetic resonance imaging

Purpose: To investigate the role of apparent diffusion coefficient (ADC) as an imaging biomarker for invasive ductal carcinoma (IDC) in the breast. @@@ Methods: Seventy-one patients undergoing 3.0 Tesla DWI were retrospectively enrolled. Correlations between the ADC values and prognostic factors were evaluated. @@@ Results: Multivariate regression analyses showed that Ki67 expression and molecular subtype were independently associated with the ADC. Discriminant analysis excluded the ADC as a good biomarker for subtype, but the mean ADC significantly distinguished Ki67-positive (low ADC) from Ki67-negative (high ADC) lesions, as observed in the in ROC curves, with a diagnostic sensitivity of 1.00 and a cut-off value of 0.97 x 10(-3)mm(2) /s. @@@ Conclusion: The ADC may be helpful for predicting Ki67 expression in IDC preoperatively.

• 出版日期2018-11
• 单位同济大学; 复旦大学