Acetylated Furostene Glycosides from Solanum gilo Fruits

作者：Tchoupang Edwige Nana; Reder Christina; Ateba Sylvin Benjamin; Zehl Martin; Kaehlig Hanspeter; Njamen Dieudonne; Hoeller Franziska; Glasl Tazreiter Sabine; Krenn Liselotte^*

来源：Planta Medica, 2017, 83(14-15): 1227-1232.

DOI：10.1055/s-0043-116491

• Solanum gilo Raddi
• Solanum aethiopicum L.
• Solanaceae
• furostene-type glycosides
• 26-[(3 ''', 4 ''', 6 '''-tri-O-acetyl)-beta-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3 beta-yl-O-alpha-L-rhamnopyranosyl-(1 ''-> 2 ')-beta-D-glucopyranoside
• 26-[(3 ''', 4 ''', 6 '''-tri-O-acetyl)-beta-D-glucopyranosyloxy]-22-hydroxy-furost-5-en-3 beta-yl-[O-alpha-L-rhamnopyranosyl-(1 ''''-> 4 ')-O-alpha-L-rhamnopyranosyl-(1 '' -> 2 ')]-beta-D-glucopyranos

In continuation of our work on a traditional mixture of spices called "Nkui", used in Cameroon for its influence on women's reproductive health, we investigated the chemical composition of Solanum gilo, one component of "Nkui". A methanolic extract was studied in detail. After dereplication of several known compounds, two furo-5-stene-derived saponin glycosides with acetylated sugar moieties were isolated. By extensive 1- and 2D NMR experiments and HR-MS and GC-MS methods, the structures were elucidated as 26-[(3, 4, 6-tri-O-acetyl)-beta-D-glucopyranosyloxy]-22-hydroxyfurost5-en-3 beta-yl-O-a-L-rhamnopyranosyl-(1 ''-> 2 ')-beta-D-glucopyranoside (A) and 26-[(3 ''', 4 ''', 6 '''-tri-O-acetyl)-beta-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3 beta-yl-[O-a-L-rhamnopyranosyl-(1 '''' -> 4 ')-O-a-L-rhamnopyranosyl-(1 ''-> 2 ')]-beta-D-glucopyranoside (B), both new natural compounds.

• 出版日期2017-10