Promoting Research in Advanced Dementia: Early Clinical Results of the Alzheimer Center Reina Sofia Foundation

作者：Olazaran Javier^*; Agueera Ortiz Luis; Osorio Ricardo S; Leon Salas Beatriz; Luis Dobato Jose; Cruz Orduna Isabel; Gonzalez Belen; Valenti Meritxell; Gil Ruiz Nuria; Frades Belen; Ramos Garcia M I; Martinez Martin Pablo

来源：Journal of Alzheimer's Disease, 2012, 28(1): 211-222.

DOI：10.3233/JAD-2011-110875

• Alzheimer's disease
• clinical research protocol
• geriatric assessment
• inpatients
• nursing homes
• outpatients
• primary senile degenerative dementia

The Alzheimer Center Reina Sofia Foundation (ACRSF) was envisaged to address the complex and multi-disciplinary research and care needs posed by Alzheimer's disease (AD) and other neurodegenerative dementias. Patients may be admitted at ACRSF either as inpatients (i.e., nursing home) or outpatients (i.e., day-care center). The research program includes clinical, social, biochemical, genetic, and magnetic resonance investigations, as well as brain donation. We present the inception of the clinical research protocol for the ACRSF, the early results, and the amendments to the protocol. Foreseen as distinct populations, inpatient and outpatient results are presented separately. Data were collected from 180 patients (153 inpatients, 27 outpatients) (86% AD), with informed consent for participation in the research program of the ACRSF. Most patients (95%) had moderate to severe dementia. Nursing home patients were older, displayed marked gait dysfunction, and were significantly more dependent in the activities of daily living (ADL), compared to the day-care patients (p < 0.05). Some cognitive, ADL, and quality of life (QoL) scales were eliminated from the protocol due to floor effect or lack of specificity of contents for advanced dementia. New measurements were added for evaluation of cognition, apathy, agitation, depression, ADL, motor function, and QoL. The final assessment is expected to be sensitive to change in all the clinical aspects of advanced degenerative dementia, to promote multidisciplinary and, desirably, inter-center collaborative research and, eventually, to contribute to the improvement of treatment and care for these patients.

• 出版日期2012