MOUSE LIVER DISPERSION FOR THE DIAGNOSIS OF EARLY-STAGE FATTY LIVER DISEASE: A 70-SAMPLE STUDY

作者：Barry Christopher T; Hah Zaegyoo; Partin Alexander; Mooney Robert A; Chuang Kuang Hsiang; Augustine Alicia; Almudevar Anthony; Cao Wenqing; Rubens Deborah J; Parker Kevin J^*

来源：Ultrasound in Medicine and Biology, 2014, 40(4): 704-713.

DOI：10.1016/j.ultrasmedbio.2013.10.016

• Fatty liver disease
• Steatosis
• Dispersion
• Crawling waves
• Shear wave elasticity imaging
• Medical ultrasound imaging
• Viscoelastic tissue models

The accumulation of fat droplets within the liver is an important marker of liver disease. This study assesses gradations of steatosis in mouse livers using crawling waves, which are interfering patterns of shear waves introduced into the liver by external sources. The crawling waves are detected by Doppler ultrasound imaging techniques, and these are analyzed to estimate the shear wave speed as a function of frequency between 200 and 360 Hz. In a study of 70 mice with progressive increases in steatosis from 0% to >60%, increases in steatosis are found to increase the dispersion, or frequency dependence, of shear wave speed. This finding confirms an earlier, smaller study and points to the potential of a scoring system for steatosis based on shear wave dispersion. (E-mail: kevin.parker@rochester.

• 出版日期2014-4