A Modular Synthesis of Salvileucalin B Structural Domains

作者:Tseng Chih Chung; Ding Hanfeng; Li Ang; Guan Yucui; Chen David Y K*
来源:Organic Letters, 2011, 13(16): 4410-4413.
DOI:10.1021/ol201748x

摘要

A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels-Alder reaction to construct domain "A", REDOX chemistry to functionalize domain "B", and a palladium-mediated cross-coupling to install domain "C". This flexible approach should facilitate further chemical and biological investigations of this fascinating class of compounds.

  • 出版日期2011-8-19