Limited protection conferred by a DNA vaccine against a lethal pseudorabies virus infection at day 5 postvaccination

作者:Dory Daniel*; Torche Anne Marie; Beven Veronique; Cariolet Roland; Jestin Andre
来源:Clinical and Vaccine Immunology, 2007, 14(4): 470-473.
DOI:10.1128/CVI.00428-06

摘要

No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs. PRV-stimulated peripheral blood mononuclear cells produced gamma interferon mRNA in vitro. Two out of five pigs recovered from lethal PRV infection without attenuation of nasal viral excretion.

  • 出版日期2007-4