A practical and straightforward access to fluorinated homoallylic alcohols in aqueous media

作者：Lemonnier Gerald; Poisson Thomas^*; Couve Bonnaire Samuel; Pannecoucke Xavier

来源：Tetrahedron Letters, 2013, 54(22): 2821-2824.

DOI：10.1016/j.tetlet.2013.03.082

• Fluorine
• Fluoroolefins
• Water

Herein, a practical and straightforward access to fluorinated homoallylic alcohols is reported. The corresponding products were obtained in good to excellent yield in brine or THF as a solvent using indium(0) and the readily available 3-chloro-2-fluoroprop-1-ene to promote the allylation reaction. This methodology affords an easy access to valuable fluorinated products under mild conditions.

• 出版日期2013-5-29