Anti-adalimumab antibodies in juvenile idiopathic arthritis: frequent association with loss of response

作者：Skrabl Baumgartner A; Erwa W; Muntean W; Jahnel J^*

来源：Scandinavian Journal of Rheumatology, 2015, 44(5): 359-362.

DOI：10.3109/03009742.2015.1022213

Objectives: We aimed to determine how loss of response (LOR) to adalimumab (ADA) in juvenile idiopathic arthritis (JIA) may be related to anti-ADA antibodies (AAA).
Method: AAA and ADA levels were measured in 23 consecutive patients with JIA responding significantly to treatment with ADA.
Results: Six out of 23 (26%) patients developed AAA and had low ADA levels. Five out of six AAA-positive patients experienced LOR. In these patients use of concomitant methotrexate (MTX) was significantly lower.
Conclusions: The occurrence of AAA is a frequent event associated with LOR. Monitoring of AAA and serum ADA levels should be considered in JIA patients under ADA therapy.

• 出版日期2015
• 单位河北医科大学