A new gorgostane derivative from the Egyptian Red Sea soft coral Heteroxenia ghardaqensis

作者:Elshamy Abdelsamed I; Abdel Razik Ayman F*; Nassar Mahmoud I; Mohamed Tahia K; Ibrahim Mohamed A; El Kousy Salah M
来源:Natural Product Research, 2013, 27(14): 1250-1254.
DOI:10.1080/14786419.2012.724417

摘要

Chemical investigation of the chloroform extract of the Egyptian Red Sea soft coral, Heteroxenia ghardaqensis (Family Xeniidae), led to the isolation of three gorgostane derivatives, namely gorgosten-5(E)-3-ol (1), gorgostan-3,5,6, 11-tetraol (sarcoaldosterol A) (2) and gorgostan-3,5,6-triol-11-acetate (3). To our knowledge, sterol 3 is reported in this article for the first time. The structure elucidation of these compounds was deduced by 1-D and 2-D NMR as well as ESIMS. Sterol 1 showed moderate activity as growth inhibitor of human colon tumour cell lines.

  • 出版日期2013-7-1