Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

作者：Sulaiman M R^*; Perimal E K; Akhtar M N; Mohamad A S; Khalid M H; Tasrip N A; Mokhtar F; Zakaria Z A; Lajis N H; Israf D A

来源：Fitoterapia, 2010, 81(7): 855-858.

DOI：10.1016/j.fitote.2010.05.009

• Zerumbone
• Anti-inflammatory activity
• Carrageenan-induced paw edema test
• Cotton pellet-induced granuloma test

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10,50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

• 出版日期2010-10