Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis

作者：Wang, Jia-Li; Xue, Li; Hao, Pan-Pan; Xu, Feng; Chen, Yu-Guo^*; Zhang, Yun

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2010, 11(2): 127-135.

DOI：10.1177/1470320310364181

• angiotensin II type 1 receptor
• hypertension
• meta-analysis
• polymorphism

Introduction. We performed a meta-analysis with the aim of assessing the association of the angiotensin II type 1 (AT(1)) receptor gene A1166C polymorphism with essential hypertension in Chinese case-control studies. Methods. Studies were searched from the Chinese Biomedicine Database, the China National Knowledge Infrastructure platform, Pubmed and Medline, using the search terms 'hypertension', 'angiotensin II type 1 receptor', 'AT(1)R', 'polymorphism', 'China' and 'Chinese', without limiting to any specific language. The strength of the association between the A1166C polymorphism and hypertension was evaluated by the odds ratio (OR) with the corresponding 95% confidence interval (CI). The analyses were performed with Cochrane RevMan software version 4.2. @@@ Results. Overall, the variant genotype AC/CC was associated with a statistically increased essential hypertension risk with the pooled OR 1.48 (95% CI: 1.20-1.83). In the subgroup analyses, the association was also significant among studies using Northern populations, Southern populations, Han Chinese and hospital-based controls. The age did not influence the relationship between the AT(1) receptor A1166C polymorphism and hypertension in the subgroup analyses. @@@ Conclusions. The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population.

• 出版日期2010-6
• 单位山东大学