alpha(4)beta(1) integrin promotes accumulation of tissue-resident memory CD8(+) T cells in salivary glands

作者：Woyciechowski Sandra; Hofmann Maike; Pircher Hanspeter^*

来源：European Journal of Immunology, 2017, 47(2): 244-250.

DOI：10.1002/eji.201646722

• alpha(4)beta(1) integrin
• Salivary glands
• Tissue-resident memory T cells (T-RM cells)
• VCAM-1
• Viral infections

The salivary glands (SGs) of virus-immune mice contain substantial numbers of tissue-resident memory CD8(+) T cells (T-RM cells) that can provide immunity to local infections. Integrins regulate entry of activated T cells into nonlymphoid tissues but the molecules that mediate migration of virus-specific CD8(+) T cells to the SGs have not yet been defined. Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8(+) TRM cells in SGs in an alpha(4)beta(1) integrin-dependent manner. After infection with lymphocytic choriomeningitis virus, accumulation of P14 TRM cells in SGs and intestine but not in kidney was also alpha(4) integrin dependent. Blockade of alpha(4)beta(7) by monoclonal antibodies (mAbs) inhibited lymphocytic choriomeningitis virus-induced accumulation of P14 TRM cells in the intestine but not in SGs. In conclusion, our data reveal that alpha(4)beta(1) integrin mediates CD8(+) TRM accumulation in SGs and that poly(I:C) can be used to direct activated CD8(+) T cells to this organ.

• 出版日期2017-2