Association of DNA repair relevant gene polymorphisms with the risk of gastric cancer in a Han Chinese population

作者：Wang, Yu; Tang, Xin; Cao, Dachun; Zhou, Kun; Sun, Gang; Liu, Hailin^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(11): 12114-12118.

• Gastric cancer
• DNA repair
• association
• polymorphism

Objective: To investigate the associations of five non-synonymous variants of four DNA repair-relevant genes with gastric cancer (GC) in a large Han Chinese population. Methods: A hospital-based case-control study, comprised of 622 patients diagnosed with gastric cancer and 622 age-and gender-matched controls, was conducted. Blood samples were collected from patients and healthy control subjects to analyze polymorphisms of XRCC1 rs1799782, rs25487, XRCC3 rs861539, hOGG1 rs1052133, and NQO1 rs1800566. Risk estimates were expressed as odds ratios (OR) and 95% confidence intervals (95% CI). Results: All five examined polymorphisms met Hardy-Weinberg equilibrium. Overall, significant differences were found in the genotype/allele distributions of rs1799782 in XRCC1, and rs1800566 in NQO1 (P < 0.05 for both), whereas no significant difference was observed among the other three variants between patients and controls (P > 0.05). The risk of gastric cancer associated with the rs1800566-T mutant allele was higher by 71% (95% CI [confidence interval]: 1.48-1.99; P < 0.001) under the additive model, and by 86% (95% CI: 1.48-2.33; P < 0.001) under the dominant model. The mutant-T allele of variant rs1799782 conferred increased GC risks of 27% (95% CI: 1.06-1.52; P = 0.009) and 42% (95% CI: 1.13-1.77; P = 0.002) under the additive and dominant models, respectively. Conclusions: Results suggest that the XRCC1 rs1799782 and NQO1 rs1800566 polymorphisms confer high susceptibility to GC in the Chinese population.

• 出版日期2016
• 单位上海交通大学