Efficacy of Pre-surgical Axitinib for Shrinkage of Inferior Vena Cava Thrombus in a Patient with Advanced Renal Cell Carcinoma

作者：Sassa Naoto^*; Kato Masashi; Funahashi Yasuhito; Maeda Motohiro; Inoue Satoshi; Gotoh Momokazu

来源：Japanese Journal of Clinical Oncology, 2014, 44(4): 370-373.

DOI：10.1093/jjco/hyu014

• renal cell carcinoma
• pre-surgical
• molecular target agents
• axitinib
• IVC thrombus

The authors present the first case report of pre-surgical axitinib treatment on primary renal tumor and vena cava thrombus. We report the case of a 78-year-old woman with renal cell carcinoma and inferior vena cava tumor thrombus, successfully downstaged with pre-surgical therapy with axitinib. A significant objective response was observed for tumor size and thrombus. After initiation of axitinib therapy, computed tomography showed a decrease, from 57 to 51 mm, in the maximal renal tumor diameter. The tumor thrombus had shortened to 42 mm and had moved to the inferior hepatic vein (Levels 43), thereby obviating the need for thoracotomy. The patient finally accepted surgical treatment. Our case was enabled to perform less surgery for advanced renal cell carcinoma with tumor thrombus using axitinib as a pre-surgical therapy.

• 出版日期2014-4