Applications of ortho-Quinone Methide Intermediates in Catalysis and Asymmetric Synthesis

作者：Pathak Tejas P; Sigman Matthew S^*

来源：Journal of Organic Chemistry, 2011, 76(22): 9210-9215.

DOI：10.1021/jo201789k

Ortho-quinone methides are important synthetic intermediates and widely implicated in biological processes. In this Synopsis, recent advances concerning the synthesis and utility of these intermediates are discussed with a particular emphasis on metal-catalyzed formation of quinone methide intermediates. Additionally, applications of these intermediates as partners in asymmetric synthesis will be discussed including methods we have developed that involve the enantioselective Pd-catalyzed formation of ortho-quinone methides and the trapping of aforementioned intermediates with diverse nucleophiles.

• 出版日期2011-11-18