Nanoencapsulation of quercetin and resveratrol into elastic liposomes

作者：Cadena Pabyton G; Pereira Marcela A; Cordeiro Rafaela B S; Cavalcanti Isabella M F; Barros Neto Benicio; Pimentel Maria do Carmo C B; Lima Filho Jose Luiz; Silva Valdinete L; Santos Magalhaes Nereide S^*

来源：Biochimica et Biophysica Acta-Biomembranes, 2013, 1828(2): 309-316.

DOI：10.1016/j.bbamem.2012.10.022

• Quercetin
• Resveratrol
• Sodium deoxycholate
• Elastic liposome
• Experimental design
• Nanotechnology

Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149 nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3 mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat.

• 出版日期2013-2