alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans

作者：Murota Kaeko; Matsuda Namiko; Kashino Yasuaki; Fujikura Yutaka; Nakamura Toshiyuki; Kato Yoji; Shimizu Ryosuke; Okuyama Syuji; Tanaka Hisashi; Koda Takatoshi; Sekido Keiko; Terao Junji^*

来源：Archives of Biochemistry and Biophysics, 2010, 501(1): 91-97.

DOI：10.1016/j.abb.2010.06.036

• Quercetin
• Bioavailability
• EMIQ
• alpha-Glucosylation
• Human

Dietary intake of quercetin is suggested to be potentially beneficial for the prevention of various diseases. We examined the effect of alpha-oligoglucosylation of the sugar moiety of quercetin monoglucoside on its bioavailability in humans. Enzymatically modified isoquercitrin (EMIQ) was prepared by enzymatic deglycosylation and the subsequent of alpha-oligoglucosylation of quercetin 3-O-beta-rutinode (rutin). The plasma level of quercetin metabolites was instantly increased by oral intake of EMIQ and its absorption efficiency was significantly higher than that of isoquercitrin (quercetin 3-O-beta-glucoside; Q3G), and rutin. The Profile of plasma quercetin metabolites after EMIQ consumption did not differ from that after Q3G consumption. The apparent log P of EMIQ indicated that EMIQ is more hydrophilic than Q3G but less than quercetin 3,4'-O-beta-diglucoside. These data indicated that enzymatic alpha-oligoglucosylation to the sugar moiety is effective for enhancing the bioavailability of quercetin glucosides in humans.

• 出版日期2010-9-1