科研之友
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摘要
ObjectiveThe objective of this pilot study is to evaluate the effects of daily duloxetine, 60-120mg, on the frequency, duration, and severity of migraine attacks and the level of disability in episodic migraineurs. %26lt;br%26gt;BackgroundThere is a need for more proven effective migraine preventive medications. Two antidepressants, both of which block serotonin and norepinephrine reuptake, have been shown to be effective in the preventive treatment of migraine. Neither has earned a level A recommendation in the 2012 guidelines of the American Academy of Neurology. Duloxetine also blocks serotonin and norepinephrine reuptake. %26lt;br%26gt;MethodsThis was a prospective, 5-visit study on duloxetine treatment of episodic migraine headache with 4-10 migraine days, and less than 15 headache days per month. Patients were titrated to a goal dose of 120mg. They were excluded if they had depression. %26lt;br%26gt;ResultsThere were 22 completers plus 5 subjects who took at least 1 dose of drug. The mean duloxetine dose was 110mg. In a modified intent-to-treat analysis, subjects went from 9.22.7 headache days per month at baseline to 4.5 +/- 3.4 headache days per month (P%26lt;.001). There were no significant differences in the average headache duration, average headache severity, maximum headache attack severity, and level of functioning. Fifty-twopercent of subjects had a 50% or greater improvement in headache days. %26lt;br%26gt;ConclusionsMigraine prophylactic treatment with high-dose duloxetine may be effective in a nondepressed individual. The reported treatment response is in line with other commonly used migraine preventives.
- 出版日期2013-10
