Differential usage of NF-kappa B activating signals by IL-1 beta and TNF-alpha in pancreatic beta cells

作者：Ortis F^*; Miani M; Colli M L; Cunha D A; Gurzov E N; Allagnat F; Chariot A; Eizirik D L

来源：FEBS Letters, 2012, 586(7): 984-989.

DOI：10.1016/j.febslet.2012.02.021

• Pancreatic beta-cell
• Cytokine
• NF-kappa B
• IKK complex
• Interleukin-1 beta

The cytokines interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induce beta-cell death in type 1 diabetes via NF-kappa B activation. IL-1 beta induces a more marked NF-kappa B activation than TNF-alpha, with higher expression of genes involved in beta-cell dysfunction and death. We show here a differential usage of the IKK complex by IL-1 beta and TNF-alpha in beta-cells. While TNF-alpha uses IKK complexes containing both IKK alpha and IKK beta, IL-1 beta induces complexes with IKKa only; this effect is achieved by induction of IKK beta degradation via the proteasome. Both IKK gamma and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1 beta-induced IKK beta degradation.

• 出版日期2012-4-5