Postoperative mortality after primary cytoreductive surgery for advanced stage epithelial ovarian cancer: A systematic review

作者：Gerestein Cornelis G^*; Damhuis Ronald A M; Burger Curt W; Kooi Geertruida S

来源：Gynecologic Oncology, 2009, 114(3): 523-527.

DOI：10.1016/j.ygyno.2009.03.011

• Postoperative mortality
• 30-day mortality
• Ovarian cancer
• Primary cytoreductive surgery
• Advanced stage

Objective. Accurate estimation of the risk of postoperative mortality (POM) is essential for the decision whether or not to perform cytoreductive surgery in a patient with advanced stage ovarian cancer. To ascertain modern reference figures, a systematic review of studies reporting POM after primary cytoreductive surgery for advanced stage epithelial ovarian cancer (EOC) was performed.
Materials and methods. A Medline search was performed to retrieve papers on primary cytoreductive surgery for advanced stage EOC. Twenty-three papers met the inclusion criteria and were reviewed.
Results. According to population-based studies, POM after primary cytoreductive surgery for EOC is 3.7% on average. Single centre studies report an average rate of 2.5%. The overall mean POM is 2.8%. POM is more frequent for elderly women and after extensive procedures. Accurate information on age-specific and procedure-specific rates could not be obtained.
Conclusion. POM rates after surgery for EOC are satisfactorily low. There is a clear need for reliable reference figures for mortality after debulking surgery in the elderly.

• 出版日期2009-9