Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD

作者：Synowiec Ewelina; Sliwinski Tomasz; Danisz Katarzyna; Blasiak Janusz; Sklodowska Anna; Romaniuk Dorota; Watala Cezary; Szaflik Jerzy; Szaflik Jacek P^*

来源：Frontiers in Bioscience, 2013, 18(1): 80-90.

DOI：10.2741/4088

• AMD
• Reactive oxygen species
• Iron
• Gene polymorphism
• NQO1
• NOS3
• NFE2L2 gene

Oxidative stress may play a role in the pathogenesis of age-related macular degeneration (AMD). In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C%26gt; T, rs1800566), NOS3 (894G%26gt;T, rs1799983) and NFE2L2 (28312647A%26gt;G, rs6726395). We found that the G/G genotype of the rs6726395 polymorphism was associated with a decreased risk of AMD wet form (OR 0.44) and on the other hand the T allele of the rs1799983 polymorphism increased such risk (OR 1.63). We also observed that the C/C-G/T combined genotype of the rs1800566 and rs1799983 polymorphisms was positively correlated with a reduced risk of AMD as well as of its dry form (OR 0.40 and 0.35). The presence of the G/T-G/G combined genotype of the rs1799983 and rs6726395 polymorphisms decreased the risk of this disease (OR 0.35). The results obtained in our study suggest a potential role of the rs1800566, rs1799983 and rs6726395 polymorphisms in the AMD pathogenesis.

• 出版日期2013-1-1