Multifocal Visual Evoked Potentials for Early Glaucoma Detection

作者：Weizer Jennifer S^*; Musch David C; Niziol Leslie M; Khan Naheed W

来源：Ophthalmic Surgery, Lasers and Imaging, 2012, 43(4): 335-340.

DOI：10.3928/15428877-20120618-07

BACKGROUND AND OBJECTIVE: To compare multifocal visual evoked potentials (mfVEP) with other detection methods in early open-angle glaucoma.
PATIENTS AND METHODS: Ten patients with suspected glaucoma and 5 with early open-angle glaucoma underwent mfVEP, standard automated perimetry (SAP), short-wave automated perimetry, frequency-doubling technology perimetry, and nerve fiber layer optical coherence tomography. Nineteen healthy control subjects underwent mfVEP and SAP for comparison. Comparisons between groups involving continuous variables were made using independent t tests; for categorical variables, Fisher's exact test was used.
RESULTS: Monocular mfVEP cluster defects were associated with an increased SAP pattern standard deviation (P = .0195). Visual fields that showed interocular mfVEP cluster defects were more likely to also show superior quadrant nerve fiber layer thinning by OCT (P = .0152).
CONCLUSION: Multifocal visual evoked potential cluster defects are associated with a functional and an anatomic measure that both relate to glaucomatous optic neuropathy. [Ophthalmic Surg Lasers Imaging 2012;43:335-340.]

• 出版日期2012-8