Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE)

作者：Semmineh Natenael B; Xu Junzhong; Skinner Jack T; Xie Jingping; Li Hua; Ayers Gregory; Quarles C Chad^*

来源：Magnetic Resonance in Medicine, 2015, 74(3): 772-784.

DOI：10.1002/mrm.25435

• dynamic susceptibility contrast
• transverse relaxation
• vascular structures
• cellular structures
• contrast agent leakage
• contrast agent equilibrium

PurposeIn brain tumor dynamic susceptibility contrast (DSC)-MRI studies, multiecho acquisition methods are used to quantify the dynamic changes in T-1 and T-2* that occur when contrast agent (CA) extravasates. Such methods also enable the estimation of the effective tissue CA transverse relaxivity. The goal of this study was to evaluate the sensitivity of the transverse relaxivity at tracer equilibrium (TRATE) to tumor cytoarchitecture.
MethodsComputational and in vitro studies were used to evaluate the biophysical basis of TRATE. In 9L, C6, and human brain tumors, TRATE, the apparent diffusion coefficient (ADC), the CA transfer constant (K-trans), the extravascular extracellular volume fraction (v(e)), and histological data were compared.
ResultsSimulations and in vitro results indicate that TRATE is highly sensitive to variations in cellular properties such as cell size and density. The histologic cell density and TRATE values were significantly higher in 9L tumors as compared to C6 tumors. In animal and human tumors, a voxel-wise comparison of TRATE with ADC, v(e), and K-trans maps showed low spatial correlation.
ConclusionThe assessment of TRATE is clinically feasible and its sensitivity to tissue cytoarchitectural features not present in other imaging methods indicate that it could potentially serve as a unique structural signature or trait of cancer. Magn Reson Med 74:772-784, 2015.

• 出版日期2015-9