A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

作者：Horton Brendan; Spranger Stefani^*

来源：Immunity, 2018, 49(1): 11-13.

DOI：10.1016/j.immuni.2018.07.001

Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.

• 出版日期2018-7-17
• 单位MIT