A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer

作者：Horn Lars Christian^*; Bilek Karl; Fischer Uta; Einenkel Jens; Hentschel Bettina

来源：Gynecologic Oncology, 2014, 134(1): 42-46.

DOI：10.1016/j.ygyno.2014.04.011

• Cervical carcinoma
• Tumor size
• Measurement
• FIGO
• Stage IB
• Bulky disease

Objectives. Limited knowledge exists about the value of tumor size in surgically treated cervical cancer (CX) using a tumor size of 2 cm as cut-off value. %26lt;br%26gt;Methods. A total of 366 cases of CX FIGO stage IB who received upfront surgery were evaluated regarding tumor size, the prediction of pelvic lymph node involvement, and recurrence-free and overall survival during a median follow-up time of 94 months. Tumors %26lt;= 2.0 cm were defined as small, tumors 2.1-4.0 cm as medium sized and those larger than 4 cm as bulky disease. %26lt;br%26gt;Results. Small tumors were seen in 28.7%, medium sized in 52.5% and bulky tumors in 18.9%. There was a significant higher frequency of pelvic lymph node involvement with increasing tumor size (13.3% vs. 23.4% vs. 43.5%, respectively; p %26lt; 0.001) and an increase of recurrent disease (6.7% vs. 18.8% vs. 29.4%, respectively; p %26lt; 0.001). The 5-year overall survival rate was significantly reduced with increasing tumor size (94.0% vs. 85.1% vs. 69.9%, respectively;p %26lt; 0.001). %26lt;br%26gt;Pelvic lymph node involvement and maximal tumor size were independent prognostic factors for both recurrence-free and overall survival in multivariate analysis. %26lt;br%26gt;Conclusions. The results support that tumor size is of prognostic impact in FIGO stage IB cervical carcinomas. A further substaging is suggested for tumors up to 4.0 cm maximum dimension using a cut-off value of 2.0 cm as discriminator. Patients with tumors %26lt;= 2.0 cm may represent low risk disease.

• 出版日期2014-7
• 单位河北医科大学