科研之友
微信
新浪微博
Facebook
分享链接
摘要
BACKGROUND %26lt;br%26gt;Aging and hypertension are well-known risk factors for cerebral white matter lesions. Prothrombotic status has been shown to be a risk factor for cardiovascular disease. In this study, we investigated the relationships among prothrombotic status, ambulatory blood pressure (ABP), and white matter hyperintensity (WMH) in elderly hypertensives. %26lt;br%26gt;METHODS %26lt;br%26gt;Measurement of prothrombin fragments 1+2 (F1+2), von Willebrand Factor (vWF) and plasminogen activator inhibitor-1 (PAI-1), ABP monitoring (ABPM), and brain magnetic resonance imaging (MRI) were performed in 514 Japanese elderly hypertensives (72.3 years old, male 37%). WMH cases were further divided into deep subcortical white matter lesion (DWML) or periventricular hyperintensity (PVH). %26lt;br%26gt;RESULTS %26lt;br%26gt;Deep WMH (DWMH) had significant positive correlations with age, use of antiplatelet agents, log F1+2, log vWF, log PAI-1, and 24-h systolic BP (SBP). PVH had significant positive correlations with age, male gender, smoking, use of antiplatelet agents, white coat hypertension (WCH), log vWF, and 24-h SBP. Severe PVH had significant positive correlations with age, use of antiplatelet agents, WCH, and 24-h SBP, and that was marginally correlated with log F1+2. In the logistic linear regression analysis, log F1+2 was significantly associated with DWMH (P %26lt; 0.01) and severe PVH (P %26lt; 0.05) adjusted for age and 24-h SBP. Log PAI-1 was significantly associated with DWMH (P %26lt; 0.05) adjusted for age and 24-h SBP. %26lt;br%26gt;CONCLUSIONS %26lt;br%26gt;In the present study, F1+2 and PAI-1 were positively associated with WMH after adjustment for 24-h SBP in elderly hypertensives. In addition to the conventional risk factors, prothrombotic status might serve as a significant determinant for WMH.
- 出版日期2012-10
