alpha-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

作者：Liu, Sa; Zhong, Chunting; Wang, Weiwei; Jia, Yongguang; Wang, Lin; Ren, Li^*

来源：Polymers, 2018, 10(2): 190.

DOI：10.3390/polym10020190

• polyrotaxane
• silver sulfadiazine
• mechanism
• antibacterial

As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of alpha-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of alpha-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

• 出版日期2018-2
• 单位华南理工大学