科研之友
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摘要
A fully palladium-catalyzed synthesis of unusual naphthoxindole alkaloids through a key intramolecular direct C-H arylation step leading to the formation of the phenanthrene core is described. The three-step process involves a highly efficient Heck coupling of aryl diazonium salts with phenyl-acrylates, giving the corresponding cis-stilbenes. Cyclization of stilbenes into phenanthrenes through a direct intramolecular C-H arylation, followed by a palladium-mediated cyclization of an amino ester, led to the formation of novel naphthoxindoles.
- 出版日期2011-8
