Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

作者：Pigossi Suzane C; Alvim Pereira Fabiano; Alvim Pereira Claudia C K; Trevilatto Paula C; Scarel Caminaga Raquel M^*

来源：Implant Dentistry, 2014, 23(6): 723-731.

DOI：10.1097/ID.0000000000000157

• dental implant loss
• interleukin-4
• polymorphisms
• haplotypes

Purpose: The purpose of this study was to investigate the association between interleukin 4 (IL4) polymorphisms/haplotypes and dental implant loss.
Materials and Methods: Two hundred and seventy eight (n = 278) unrelated patients were divided into 2 groups: (1) control group (C) composed of 186 individuals presenting at least 1 osseointegrated implant and (2) study group (S) composed of 94 individuals presenting at least 1 implant loss. After DNA collection, IL4 polymorphisms were investigated by polymerase chain reaction (PCR)restriction fragment length polymorphism and for the variable number of tandem repeat (VNTR) only by PCR.
Results: No association between alleles/genotypes of -590 (C/T) (P = 0.9704/P = 0.5992) and VNTR (P = 0.7155/P = 0.8789) polymorphisms and implant loss were found between the groups. Regarding +33 (C/T) polymorphism, no difference was found in genotype frequency (P = 0.1288), but the C allele was associated with implant loss (P = 0.0236, odds ratio = 1.61, 95% confidence interval = 1.1-2.4). Haplotype analysis showed no statistical differences between the groups.
Conclusion: The C allele of the +33 (C/T) polymorphism in the IL4 gene was associated with susceptibility to dental implant loss in Brazilians in the studied population.

• 出版日期2014-12
• 单位Univ Estadual Paulista