Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1

Sibon David<sup>*</sup>; Cassar Olivier; Duga Isabelle; Brouzes Chantal; Ghez David; Pasquier Christophe; Sibon Claire; Desrames Alexandra; Mortreux Franck; Wattel Eric; Bazarbachi Ali; Gessain Antoine; Hermine Olivier

doi:10.1093/ofid/ofv032

登录

免费注册

赞收藏引用

科研之友

微信

新浪微博

Facebook

分享链接

Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1

作者：Sibon David^*; Cassar Olivier; Duga Isabelle; Brouzes Chantal; Ghez David; Pasquier Christophe; Sibon Claire; Desrames Alexandra; Mortreux Franck; Wattel Eric; Bazarbachi Ali; Gessain Antoine; Hermine Olivier

来源：Open Forum Infectious Diseases, 2015, 2(2): ofv032-ofv032.

DOI：10.1093/ofid/ofv032

摘要

Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding.