Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized phase 2 trial

作者：Kantarjian Hagop^*; Pasquini Ricardo; Hamerschlak Nelson; Rousselot Philippe; Holowiecki Jerzy; Jootar Saengsuree; Robak Tadeusz; Khoroshko Nina; Masszi Tamas; Skotnicki Aleksander; Hellmann Andrzej; Zaritsky Andrey; Golenkov Anatoly; Radich Jerald; Hughes Timothy; Countouriotis Athena; Shah Neil

来源：Blood, 2007, 109(12): 5143-5150.

DOI：10.1182/blood-2006-11-056028

Therapeutic options for chronic myelogenous leukemia (CML) resistant to 400 to 600 mg imatinib are limited. Escalating imatinib doses may overcome resistance. Dasatinib, a significantly more potent inhibitor of BCR-ABL, is safe and effective in this population. Patients with imatinibresistant chronic-phase (CP) CML were randomized 2:1 to 140 mg dasatinib (n = 101) or 800 mg imatinib (n = 49). With a median follow up of 15 months, complete hematologic responses were observed in 93% and 82% of patients receiving dasatinib and high-dose imatinib (P =.034), respectively. Dasatinib resulted in higher major cytogenetic response rates (52%) than high-dose imatinib (33%) (P =.023); this included complete cytogenetic response in 40% and 16% (P =.004). Major molecular responses were also more frequent with dasatinib (16% versus 4%; P = 0.038). Treatment failure (hazard ratio [HR], 0.16; P <.001) and progression-free survival (HR, 0.14; P<.001) both favored dasatinib. Superficial edema (42% versus 15%) and fluid retention (45% versus 30%) were more prevalent with imatinib; pleural effusion was more common with dasatinib (117% versus 0%). Grade 3 to 4 nonhematologic toxicity was minimal. Cytopenias were more frequent and severe with dasatinib. Dasatinib represents a safe and effective therapy for CP-CML resistant to conventional imatinib doses with improved cytogenetic and molecular response rates and progression-free survival relative to high-dose imatinib.

• 出版日期2007-6-15
• 单位河北医科大学