Alkaloid induced asymmetric electrocarboxylation of 4-methylpropiophenone

作者：Zhao, Shu Feng; Zhu, Mei Xia; Zhang, Kai; Wang, Huan^*; Lu, Jia Xing

来源：Tetrahedron Letters, 2011, 52(21): 2702-2705.

DOI：10.1016/j.tetlet.2011.03.076

• Cinchonine
• Induction
• Electrocarboxylation
• Enantiomeric excess
• Carbon dioxide

The alkaloid-induced electrocarboxylation of 4-methylpropiophenone is examined in mild conditions. Comparative studies with several inductors indicate that the efficient enantiodiscrimination of the electrocarboxylation depends on the nucleophilic quinuclidine nitrogen atom and the OH group of the inductors.

• 出版日期2011-5-25
• 单位华东师范大学