An acquired, calcium-dependent, factor X inhibitor

作者：Broze George J Jr^*

来源：Blood Cells, Molecules, and Diseases, 2014, 52(2-3): 116-120.

DOI：10.1016/j.bcmd.2013.09.001

• Factor X
• Inhibitor
• Acquired
• Calcium-dependent

Acquired factor X (FX) deficiency unrelated to amyloidosis is a rare disorder in which an anti-FX antibody is infrequently detected. A patient with severe bleeding due to a calcium ion-dependent anti-FX IgG antibody is described. The FX affinity purified IgG bound the light chain of FX, but not FX lacking its gamma-carboxyglutamic acid domain, and binding was enhanced >1000-fold in the presence of calcium ions. The antibody also recognized prothrombin and factor VII with about 100-fold and 1000-fold lower affinity. Like a lupus anticoagulant, increasing concentrations of phospholipids in functional assays reduced the inhibitory activity of the antibody. The effect of these properties of the inhibitor on laboratory diagnostic studies is considered.

• 出版日期2014-3