Promoter variation in the catechol-O-methyltransferase gene is associated with remission of symptoms during fluvoxamine treatment for major depression

作者：Fukui Naoki; Suzuki Yutaro; Sugai Takuro; Watanabe Junzo; Ono Shin; Tsuneyama Nobuto; Someya Toshiyuki^*

来源：Psychiatry Research, 2014, 218(3): 353-355.

DOI：10.1016/j.psychres.2014.04.030

• COMT
• Depression
• Fluvoxamine

We investigated the association between remission of depressive symptoms in fluvoxamine treatment and catechol-O-methyltransferase (COMT) gene. Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression. Three single nucleotide polymorphisms located in the 5%26apos; region were associated with remission in fluvoxamine-treated outpatients with moderate to severe depression.

• 出版日期2014-8-30